It looks like the Clay Mathematics Institute (CMI) is parting with its first one million USD. Indeed, today the CMI announced that Grigoriy Perelman is the recipient of the Millennium Prize for the resolution of the Poincaré conjecture. Full details are here and a full-length press release is also available.
What do you think will be the next Millennium Prize Problem to fall? It seems very unlikely that it will be our own P vs. NP problem, but, as Bohr taught us, “Prediction is very difficult, especially about the future".